49 US AI Startups That Surged Past $100M in Funding in 2025

Last year marked a significant milestone for the AI sector in the United States, with 49 startups successfully securing funding rounds of $100 million or more in 2024. Within this number, three startups achieved more than one “mega-round,” while seven managed to raise funding rounds worth $1 billion or more. As we near the end of 2025, predictions loom about the year’s performance in comparison to the last.

So far, 2025 has matched 2024’s figures concerning startups raising rounds of $100 million and larger, with a noticeable increase in the number of companies that have successfully completed multiple funding rounds exceeding that threshold.

Here are the key U.S. AI startups that have raised $100 million or more throughout 2025:

November

• Anysphere, known for its viral vibe-coding platform Cursor, raised $2.3 billion in a funding round that valued the company at $29.3 billion. This was its second funding round this year.
• Parallel, focused on web infrastructure for AI agents, completed a $100 million Series A round around November 12, co-led by Index Ventures and Kleiner Perkins.
• Hippocratic AI, a healthcare AI startup, raised $126 million in Series C, bringing its valuation to $3.5 billion.

October

• Fireworks AI, a platform for building AI applications using open-source models, raised $250 million Series C, leading to a valuation of $4 billion.
• Uniphore, specializing in enterprise AI, raised $260 million Series F, achieving a valuation of $2.5 billion.
• Sesame, a voice AI company, secured $250 million Series B, co-led by Sequoia and Spark Capital, valuing it at $X.
• OpenEvidence received $200 million Series C, arriving at a valuation of $6 billion.
• Lila Sciences raised $350 million Series A, with co-leads including Braidwell and Collective Global.
• Reflection AI announced a massive $2 billion Series B for its entrepreneurial advances, establishing an $8 billion valuation.
• EvenUp, focused on AI for legal personal injury, raised $150 million Series E, achieving a valuation above $2 billion.

September

• Periodic Labs raised $300 million seed round, led by Felicis and Andreessen Horowitz.
• Cerebras Systems completed a $1.1 billion Series G round, raising its valuation to $8.1 billion.
• Modular secured $250 million in funding, focused on its compute layer initiative.
• Distyl AI raised $175 million Series B, attaining a valuation of $1.8 billion.

August

• EliseAI raised $250 million Series E, reaching a valuation of $2.2 billion.
• Decart, an AI research lab, garnered $100 million in funding at a $3.1 billion valuation.

Previous Months

Throughout the earlier months of 2025, numerous other startups also made significant funding announcements, including AI firms specializing in healthcare, enterprise solutions, and generative AI technologies, further demonstrating the accelerating growth and interest in the AI landscape.

As 2025 progresses, the momentum continues to build within the AI sector, suggesting a promising year ahead, closely scrutinized against the monumental achievements of 2024. For further information regarding the full list and details of funding rounds, refer to TechCrunch’s dedicated coverage.

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